Determination of Tobacco Specific Nitrosamines in Cigarette Mainstream Smoke – Gc-tea Method
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چکیده
Between 1999 and 2005, a Task Force composed of CORESTA members has studied the existing methodologies for the determination of the Tobacco Specific Nitrosamines (TSNAs) in the mainstream smoke of cigarettes. Several methods have been proposed for this determination, which are mainly based on two types of analytical methodologies: GC-TEA (Gas Chromatography with a Thermal Energy Analyser as detector) and LC/MS/MS.
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Analysis of Carcinogenic Tobacco- Specific Nitrosamines in Mainstream Cigarette Smoke Using an Agilent J&W DB-35ms Ultra Inert GC Column
A simple and sensitive method for routine analysis of TSNAs in mainstream cigarette smoke has been developed. Cigarette smoke particulate matter was collected according to ISO 4387. The particulate matter was extracted with methylene chloride, cleaned up with an Agilent Bond Elut Alumina B SPE cartridge, and analyzed using an Agilent 7000A Triple Quadrupole GC/MS system with an Agilent J&W DB-3...
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